Title: "Strong Love" Title: "Strong Love"
Agency: JWT Co., LTD.
City: Bangkok
Advertiser: Pfizer
Brand Name: Viagra
Country of Production: Thailand
Type: Outdoor / Out of Home
Awards: Asia Pacific Advertising Festival (AP AdFest), 2007 (Bronze) for Single Execution for Innovation use of non-conventional outdoor media
Men who take Viagra “put their fertility at risk” 威而鋼助性 反而斷生機
【This article appeared in the Observer on Sunday February 24 2008】
Using Viagra may be damaging men's fertility, researchers have warned. Experiments suggest that the anti-impotence drug can harm sperm and may prevent some men from fathering families.
In particular, young men who use the drug recreationally could impair their ability to have families. And fertility clinics that prescribe Viagra to help men produce sperm for IVF treatments could be preventing some couples from conceiving.
I think it is worrying that some IVF clinics are using Viagra in order to boost fertility results,' said Dr David Glenn, a consultant gynaecologist at Queen's University Belfast. 'Couples that go there for treatment are, by definition, already having problems getting pregnant. Giving male partners something that could make the problem worse is scarcely the right approach.'
Glenn's research, which is to be published in the journal Fertility and Sterility, is based on two sets of experiments. The first involved taking sperm samples from volunteers and then bathing them in weak solutions of Viagra. The aim was to produce a Viagra level equivalent to that found in the blood of a man who had taken a single 100-milligram tablet.
The researchers then compared the behaviour of the treated sperm with standard samples and found the drug had two principal effects. It made sperm more active but also it damaged its acrosome, a cap-like structure that contains enzymes that break down the membrane surrounding a woman's egg and allows sperm to fertilise it.
'Essentially the acrosome breaks open too early in sperm that has been exposed to Viagra. The sperm cannot get into the egg and so it is not fertilised,' said Glenn.
His team carried out similar experiments on animals and found that sperm from mice that had been given Viagra produced 40 per cent fewer embryosthan those on control pills. However, there was no evidence that baby mice produced by male mice on Viagra had been damaged in any way.
'There are two main concerns raised by these findings,' Glenn told The Observer. 'First, Viagra has become a widely used recreational drug. It is mixed with cocaine, for example, and is sold in clubs. Our work leaves open the possibility that there could be a cumulative effect from taking Viagra, however, which could pose serious fertility problems in later life.'
Glenn's work also suggests that the use of Viagra by IVF clinics could pose problems for many couples. Last week The Observer contacted a number of British IVF clinics to ask if they administered Viagra to men. Several said they did. Others, such as the clinic at University College Hospital in London, said did not because it had been found that Viagra could damage sperm.
威而鋼助性 反而斷生機,有損精子進入卵子受精酵素
英國研究人員警告說，壯陽藥物威而鋼可能傷害男性的精子，因而損及男性的生育能力。年輕男性如果偶爾服用威而鋼助興，未來可能因此無法建立家庭，有些不孕症診所也常開立威而鋼，幫助男方製造更多精子進行試管嬰兒療程，反而會影響求診夫婦的受孕機會。
根據英國觀察家報報導指出，北愛爾蘭貝爾發斯特女王大學婦產科教授葛倫在研究中進行了兩組實驗，研究人員先將第一組男性志願者的精子放進威而鋼的稀釋溶液中，以模擬一百毫克威而鋼錠劑在服用者血液中的濃度，接著再把這批精子與第二組的一般精子進行比較。結果研究人員發現，威而鋼雖能讓精子更活躍，卻也會損及精子的頂體（acrosome）功能，精子的頂體是一種帽狀結構，其中含有能穿透女性卵子、讓精子得以進入卵子內受精的酵素。
葛倫表示，放進威而鋼溶液中的精子頂體太早破裂，因此無法游到卵子附近使卵子受精。這項研究即將刊登在「生殖與不孕」期刊上。
葛倫的研究團隊也對動物進行了類似實驗，結果發現老鼠服用威而鋼後，其精子成功受精產生的胚胎數量比對照組少了四十％，但服用威而鋼雄鼠所產下的後代並未出現任何異狀。
台大婦產部主治醫師陳信孚表示，這篇研究僅為體外試驗，未來在人體試驗時，不一定會得到相同結果，因為體內與體外的環境大不相同，人體體液中有很多物質，可能加強或減少威而鋼對精子的潛在傷害，精子的受孕能力不見得一定會受影響。
陳信孚表示，在缺乏大規模的人體研究前，服用威而鋼後是否會傷害男性精子，還不能驟下結論。在他的不孕症門診中，他也從未明顯感受到男性病患服用威而鋼後，精子受孕能力出現明顯惡化，「就算真的有負面影響，可能也不明顯」。
Agency: JWT Co., LTD.
City: Bangkok
Advertiser: Pfizer
Brand Name: Viagra
Country of Production: Thailand
Type: Outdoor / Out of Home
Awards: Asia Pacific Advertising Festival (AP AdFest), 2007 (Bronze) for Single Execution for Innovation use of non-conventional outdoor media
Men who take Viagra “put their fertility at risk” 威而鋼助性 反而斷生機
【This article appeared in the Observer on Sunday February 24 2008】
Using Viagra may be damaging men's fertility, researchers have warned. Experiments suggest that the anti-impotence drug can harm sperm and may prevent some men from fathering families.
In particular, young men who use the drug recreationally could impair their ability to have families. And fertility clinics that prescribe Viagra to help men produce sperm for IVF treatments could be preventing some couples from conceiving.
I think it is worrying that some IVF clinics are using Viagra in order to boost fertility results,' said Dr David Glenn, a consultant gynaecologist at Queen's University Belfast. 'Couples that go there for treatment are, by definition, already having problems getting pregnant. Giving male partners something that could make the problem worse is scarcely the right approach.'
Glenn's research, which is to be published in the journal Fertility and Sterility, is based on two sets of experiments. The first involved taking sperm samples from volunteers and then bathing them in weak solutions of Viagra. The aim was to produce a Viagra level equivalent to that found in the blood of a man who had taken a single 100-milligram tablet.
The researchers then compared the behaviour of the treated sperm with standard samples and found the drug had two principal effects. It made sperm more active but also it damaged its acrosome, a cap-like structure that contains enzymes that break down the membrane surrounding a woman's egg and allows sperm to fertilise it.
'Essentially the acrosome breaks open too early in sperm that has been exposed to Viagra. The sperm cannot get into the egg and so it is not fertilised,' said Glenn.
His team carried out similar experiments on animals and found that sperm from mice that had been given Viagra produced 40 per cent fewer embryosthan those on control pills. However, there was no evidence that baby mice produced by male mice on Viagra had been damaged in any way.
'There are two main concerns raised by these findings,' Glenn told The Observer. 'First, Viagra has become a widely used recreational drug. It is mixed with cocaine, for example, and is sold in clubs. Our work leaves open the possibility that there could be a cumulative effect from taking Viagra, however, which could pose serious fertility problems in later life.'
Glenn's work also suggests that the use of Viagra by IVF clinics could pose problems for many couples. Last week The Observer contacted a number of British IVF clinics to ask if they administered Viagra to men. Several said they did. Others, such as the clinic at University College Hospital in London, said did not because it had been found that Viagra could damage sperm.
威而鋼助性 反而斷生機,有損精子進入卵子受精酵素
英國研究人員警告說，壯陽藥物威而鋼可能傷害男性的精子，因而損及男性的生育能力。年輕男性如果偶爾服用威而鋼助興，未來可能因此無法建立家庭，有些不孕症診所也常開立威而鋼，幫助男方製造更多精子進行試管嬰兒療程，反而會影響求診夫婦的受孕機會。
根據英國觀察家報報導指出，北愛爾蘭貝爾發斯特女王大學婦產科教授葛倫在研究中進行了兩組實驗，研究人員先將第一組男性志願者的精子放進威而鋼的稀釋溶液中，以模擬一百毫克威而鋼錠劑在服用者血液中的濃度，接著再把這批精子與第二組的一般精子進行比較。結果研究人員發現，威而鋼雖能讓精子更活躍，卻也會損及精子的頂體（acrosome）功能，精子的頂體是一種帽狀結構，其中含有能穿透女性卵子、讓精子得以進入卵子內受精的酵素。
葛倫表示，放進威而鋼溶液中的精子頂體太早破裂，因此無法游到卵子附近使卵子受精。這項研究即將刊登在「生殖與不孕」期刊上。
葛倫的研究團隊也對動物進行了類似實驗，結果發現老鼠服用威而鋼後，其精子成功受精產生的胚胎數量比對照組少了四十％，但服用威而鋼雄鼠所產下的後代並未出現任何異狀。
台大婦產部主治醫師陳信孚表示，這篇研究僅為體外試驗，未來在人體試驗時，不一定會得到相同結果，因為體內與體外的環境大不相同，人體體液中有很多物質，可能加強或減少威而鋼對精子的潛在傷害，精子的受孕能力不見得一定會受影響。
陳信孚表示，在缺乏大規模的人體研究前，服用威而鋼後是否會傷害男性精子，還不能驟下結論。在他的不孕症門診中，他也從未明顯感受到男性病患服用威而鋼後，精子受孕能力出現明顯惡化，「就算真的有負面影響，可能也不明顯」。
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